Hinweis: Die Achievement-Liste kann unter Umständen Spoiler zur Story u.ä. Inhalten von Mega Man 10 sowie versteckte Erfolge enthalten. Auf der Xbox 360 gibt es insgesamt 12 Erfolge und 200 Gamerscore zu holen.

• 

  WHOMP WILY!

  Clear the game once.

• 

  BLUE BOMBER

  Clear the game in under an hour.

• 

  SUPERHERO

  Clear the game on HARD.

• 

  HARD ROCK

  Make it to a boss room without getting damaged.

• 

  HEADBANGING

  Defeat the 8 bosses without your helmet on.

• 

  DESTROYER

  Defeat 1000 enemies.

• 

  WORLD WARRIOR

  Defeat one of every type of enemy.

• 

  TRUSTY SIDEARM

  Defeat the 8 bosses with just your default weapon.

• 

  NO COFFEE BREAK

  Clear the game without using any energy, mystery, or weapon tanks.

• 

  TENACIOUS

  Clear the game without continuing.

• 

  INVINCIBLE

  Clear the game without dying.

• 

  MR.PERFECT

  Clear the game without getting damaged.